Endocrine Abstracts

Purpose: Individuals with mood disorders and schizophrenia (SCZ) exhibit altered function of the HPA axis in response to stress. The glucocorticoid receptor (GR) plays an important role in negative feedback regulation of the HPA-axis. There are two protein isoforms, GRα and GRβ, which have activating and blocking activity respectively. In line with aberrant expression of GR mRNA in the brains of depressed, SCZ and bipolar (BD) patients (1), lymphocytes of depressed, ...